Activation and control of immune cells within the cardiac muscle and the pericardium are acknowledged as crucial mechanisms in cardiac conditions. Grasping the dynamics and aiming to influence the interplay between innate and adaptive immune cells alongside cardiomyocytes and cardiac stromal cells holds the promise of shaping forthcoming treatments for patients dealing with cardiomyopathy and heart failure. The Cardioimmunology Würzburg 2024 event will spotlight advanced research at the intersection of immunology and cardiology, offering a glimpse into the latest advancements in directing therapeutic interventions for cardiac inflammation.